Nakagawa S, Toda S, Abe Y, Yamashita H, Fujisawa K I, Naito T, Kawaguchi H
J Antibiot (Tokyo). 1978 Jul;31(7):675-80. doi: 10.7164/antibiotics.31.675.
Four N-ethyl derivatives of kanamycin A and five N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives.
