1-N-(1,3-二羟基-2-丙基)卡那霉素B（UK-31,214）的合成与抗菌活性
Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214).
作者信息
Richardson K, Brammer K W, Jevons S, Plews R M, Wright J R
出版信息
J Antibiot (Tokyo). 1979 Oct;32(10):973-7. doi: 10.7164/antibiotics.32.973.
PMID:528375
Abstract
1-N-(1,3-Dihydroxy-2-propyl)kanamycin B was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin B and gentamicin. This kanamycin B derivative (code No. UK-31,214) demonstrated potent activity in all of these tests and gave good protection in experimental infections in mice.
摘要
制备了1-N-(1,3-二羟基-2-丙基)卡那霉素B，并将其对氨基糖苷类敏感和耐药菌的体外活性与卡那霉素B和庆大霉素进行了比较。这种卡那霉素B衍生物（编号UK-31,214）在所有这些试验中均表现出强效活性，并在小鼠实验性感染中提供了良好的保护作用。
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