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Synthesis and antibacterial activities of 1-N [(S)-omega-amino-2-hydroxyalkyl] kanamycin A derivatives.

作者信息

Richardson K, Jevons S, Moore J W, Ross B C, Wright J R

出版信息

J Antibiot (Tokyo). 1977 Oct;30(10):843-6. doi: 10.7164/antibiotics.30.843.

DOI:10.7164/antibiotics.30.843
PMID:591447
Abstract

Four 1-N-aminohydroxy-alkyl derivatives of kanamycin A were prepared and their in vitro activities against aminoglycoside-sensitive and aminoglycoside-resistant organisms were compared with amikacin. 1-N-[(S)-4-Amino-2-hydroxybutyl] kanamycin A (Fig. 1, compound 2, code no. UK-18,892) was equipotent to amikacin in all these tests and in mouse protection studies.

摘要

相似文献

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Synthesis and antibacterial activities of 1-N [(S)-omega-amino-2-hydroxyalkyl] kanamycin A derivatives.
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Ann Microbiol (Paris). 1979 Apr;130A(3):331-43.

引用本文的文献

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Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3'-deoxykanamycin A and gentamicin B.双去氧卡那霉素、5-脱氧双去氧卡那霉素、3'-脱氧卡那霉素A和庆大霉素B的1-N-[(S)-ω-氨基-2-羟烷基]衍生物的合成及抗菌活性
J Antibiot (Tokyo). 2015 Jun;68(6):421-3. doi: 10.1038/ja.2015.6. Epub 2015 Feb 25.
2
Aminoglycoside research 1975-1985: prospects for development of improved agents.1975 - 1985年氨基糖苷类药物研究：改进型药物的开发前景
Antimicrob Agents Chemother. 1986 Apr;29(4):543-8. doi: 10.1128/AAC.29.4.543.
3
UK-18,892: resistance to modification by aminoglycoside-inactivating enzymes.
UK-18,892：对氨基糖苷类失活酶修饰具有抗性。
Antimicrob Agents Chemother. 1978 Dec;14(6):846-50. doi: 10.1128/AAC.14.6.846.
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In vitro studies with UK-18,892, a new aminoglycoside antibiotic.使用新型氨基糖苷类抗生素UK-18,892进行的体外研究。
Antimicrob Agents Chemother. 1978 Sep;14(3):277-80. doi: 10.1128/AAC.14.3.277.
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Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs.新型半合成氨基糖苷类抗生素布替卡星（UK-18,892）对豚鼠的耳蜗毒性
Antimicrob Agents Chemother. 1979 Sep;16(3):362-5. doi: 10.1128/AAC.16.3.362.
6
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Antimicrob Agents Chemother. 1978 Aug;14(2):228-33. doi: 10.1128/AAC.14.2.228.