用三硝基苯酚预先替代靶细胞，并不会改变细胞毒性T细胞所识别的病毒特异性修饰的诱导过程。
Induction of virus-specific modifications recognized by cytotoxic T cells is not altered by prior substitution of target cells with trinitrophenol.
作者信息
Biddison W E, Snodgrass H R, Bennink J, Effros R B, Doherty P C
出版信息
J Exp Med. 1977 Aug 1;146(2):617-22. doi: 10.1084/jem.146.2.617.
Abstract
Cytotoxic thymus-derived lymphocytes generated after interaction with trinitrophenyl (TNP)-substituted or virus-infected cells only lyse H-2 compatible target cells modified with the component used to immunize (TNP or virus). Prior saturation of TNP-reactive sites inhibits neither the infectivity of influenza A viruses, nor the capacity of infected cells to develop antigenic changes recognized by influenza-immune T cells. The two antigens are distinct entities on the cell membrane and do not obviously compete to form interactions with H-2 molecules.
摘要
与三硝基苯基（TNP）取代的或病毒感染的细胞相互作用后产生的细胞毒性胸腺来源淋巴细胞，仅裂解用用于免疫的成分（TNP或病毒）修饰的H-2相容靶细胞。TNP反应位点的预先饱和既不抑制甲型流感病毒的感染性，也不抑制感染细胞产生被流感免疫T细胞识别的抗原变化的能力。这两种抗原是细胞膜上的不同实体，不会明显竞争与H-2分子形成相互作用。
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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.在同基因或半同种异体系统中淋巴细胞性脉络丛脑膜炎体外T细胞介导的细胞毒性的限制。
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Functional interactions of viral and histocompatibility antigens at tumor cell surfaces.肿瘤细胞表面病毒抗原与组织相容性抗原的功能相互作用。
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Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells.细胞毒性T淋巴细胞识别同种异体耐受的三硝基苯结合细胞。
Nature. 1976 May 13;261(5556):141-2. doi: 10.1038/261141a0.
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