Unger W G, Butler J M, Morsi E E
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;214(1):39-46. doi: 10.1007/BF00414535.
Injection of Shigella endotoxin (2 mug) into the vitreous chamber of a normal rabbit eye induces on infiltration of polymorphonuclear leucocytes, miosis, a moderately intense dilation of iris, conjunctival and limbal vessels, and a breakdown in the blood-aqueous and blood-vitreal barriers. Significant amounts of soluble blood protein and prostaglandin-like (PG) material are found in the aqueous and vitreous humours withdrawn at 24 h. Endotoxin injected into the sensory denervated eye elicits similar vascular changes which appear to occur less rapidly than in normal eyes. conversely, the levels of aqueous and vireal PG-like material, as well as the capacity of excised irides to form PG from exogenous precursors, seems greater in the denervated eyes. If PG is an important mediator of ocular changes in the early phases, the results suggest that the action of this inflammatory autacoid in facilitating the ocular changes is less effective in eyes deprived of functional sensory nerves.
向正常兔眼玻璃体内注射2微克志贺氏菌内毒素会引起多形核白细胞浸润、瞳孔缩小、虹膜适度强烈扩张、结膜和角膜缘血管扩张以及血-房水和血-玻璃体屏障破坏。在24小时抽取的房水和玻璃体液中发现了大量可溶性血液蛋白和前列腺素样（PG）物质。注入感觉神经去支配眼的内毒素会引发类似的血管变化，但其出现速度似乎比正常眼慢。相反，去支配眼的房水和玻璃体中PG样物质的水平，以及离体虹膜从外源性前体形成PG的能力似乎更高。如果PG是早期眼部变化的重要介质，那么结果表明，这种炎症自分泌物质在促进眼部变化方面的作用在缺乏功能性感觉神经的眼中效果较差。
