夜猴的裂殖子疫苗接种预防恶性疟原虫疟疾
Merozoite vaccination of douroucouli monkeys against falciparum malaria.
作者信息
Mitchell G H, Richards W H, Butcher G A, Cohen S
出版信息
Lancet. 1977 Jun 25;1(8026):1335-8. doi: 10.1016/s0140-6736(77)92551-x.
Erythrocytic merozoites of Plasmodium falciparum (Gambia) were isolated from cultures of schizont-infected human red cells on CF 11 cellulose columns. Douroucouli monkeys vaccinated with such preparations stored in liquid nitrogen and then emulsified in Freund's complete adjuvant (F.C.A.), were resistant to successive challenges with West African (Lagos) and East African (Uganda Palto-Alto) strains of P. falciparum. The induced immunity is specific since vaccination with P. knowlesi merozoites in F.C.A. does not modify the course of P. falciparum infections in douroucouli monkeys.
恶性疟原虫（冈比亚株）的红细胞内裂殖子从裂殖体感染的人红细胞培养物中，通过CF 11纤维素柱分离得到。将液氮保存后用弗氏完全佐剂（F.C.A.）乳化的此类制剂接种夜猴，这些夜猴对西非（拉各斯）和东非（乌干达帕托 - 阿尔托）恶性疟原虫株的连续攻击具有抗性。诱导的免疫是特异性的，因为用诺氏疟原虫裂殖子在F.C.A.中接种不会改变夜猴体内恶性疟原虫感染的进程。
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