Siddiqui W A
Science. 1977 Jul 22;197(4301):388-9. doi: 10.1126/science.406671.
This is the first report of successful immunization of experimental monkeys against a human malaria parasite, Plasmodium falciparum. Of the five owl monkeys (Aotus trivirgatus) used in this pilot study, two served as controls and the other three were immunized with P. falciparum antigen consisting primarily of mature segmenters containing fully developed merozoites. Two injections of antigen emulsified with Freund's complete adjuvant were administered intramuscularly 3 weeks apart. Three weeks after the second vaccination, all monkeys were challenged with the homologous strain of P. falciparum. The control monkeys died with high levels of parasitemia within 2 weeks of challenge. The three immunized monkeys survived and showed strong protection against P. falciparum. These results are encouraging for the possible future development of an effective vaccine against human malaria.
这是关于实验猴成功免疫人类疟原虫——恶性疟原虫的首份报告。在这项初步研究中使用的五只夜猴（Aotus trivirgatus）里，两只作为对照，另外三只用主要由含有完全发育裂殖子的成熟裂殖体组成的恶性疟原虫抗原进行免疫。每隔3周肌肉注射两次与弗氏完全佐剂乳化的抗原。第二次接种疫苗3周后，所有猴子都用恶性疟原虫的同源菌株进行攻击。对照猴在攻击后2周内死于高血寄生虫血症。三只免疫的猴子存活下来，并对恶性疟原虫表现出强大的抵抗力。这些结果对于未来开发有效的人类疟疾疫苗具有鼓舞作用。
