McKechnie N M, Foulds W S
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;212(3-4):271-83. doi: 10.1007/BF00410521.
The retinae of anaesthetised Dutch rabbits were exposed to one of two intensities of white light for a period of 1 h. After exposure the animals were allowed to recover for various periods up to 4 weeks. The animals were then killed, and retinal and choroidal tissue was taken for investigation by both light and electron microscopy. Exposure to the lower intensity produced disruption of the visual cell outer segments and distension of the pigment epithelium. Recovery from this insult was rapid although disturbances in rod disc stacking and a loss of cone cell outer segments were evident 4 weeks after exposure. Exposure to the higher intensity resulted in necrosis of visual cells and pigment epithelial cells. Non-native phagocytic cells were active in the removal of cellular debris. Recovery from this insult was not observed. Four weeks after exposure much of the previously illuminated retina was reduced to disorganised Müller cells and occasional macrophages.
将麻醉后的荷兰兔视网膜暴露于两种强度的白光之一，持续1小时。暴露后，让动物恢复不同时长，最长可达4周。然后处死动物，取视网膜和脉络膜组织进行光学显微镜和电子显微镜检查。暴露于较低强度的白光会导致视觉细胞外段破坏和色素上皮膨胀。尽管暴露4周后杆状盘堆叠紊乱和锥体细胞外段丢失明显，但这种损伤的恢复很快。暴露于较高强度的白光会导致视觉细胞和色素上皮细胞坏死。非天然吞噬细胞积极清除细胞碎片。未观察到这种损伤的恢复。暴露4周后，之前受光照的大部分视网膜已退化为无序的米勒细胞和偶尔的巨噬细胞。
