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实验性视网膜脱离中视网膜色素上皮和视网膜巨噬细胞的观察

Observations on the retinal pigment epithelium and retinal macrophages in experimental retinal detachment.

作者信息

Johnson N F, Foulds W S

出版信息

Br J Ophthalmol. 1977 Sep;61(9):564-72. doi: 10.1136/bjo.61.9.564.

DOI:10.1136/bjo.61.9.564
PMID:921919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043049/
Abstract

After experimental retinal detachment in rabbits macrophages are a prominent feature in the subretinal space or within the retina. Two sources for these macrophages are identified. The retinal pigment epithelium (RPE) may undergo metaplasia and actively 'bud'; the evolving macrophage is then formed by a vitreal protrusion of the cytoplasm of an RPE cell which is 'nipped off' by lateral protrusions from adjacent cells. In addition, in regions of RPE proliferation, blood-borne cells were found in Bruch's membrane and among the mass of proliferated RPE cells, suggesting that blood-borne cells may pass from the choroidal circulation through Bruch's membrane and the RPE layer.

摘要

在兔实验性视网膜脱离后，巨噬细胞是视网膜下间隙或视网膜内的一个显著特征。已确定这些巨噬细胞有两个来源。视网膜色素上皮（RPE）可能发生化生并积极“出芽”；然后，一个RPE细胞的细胞质向玻璃体突出，被相邻细胞的侧向突出“掐断”，从而形成正在演变的巨噬细胞。此外，在RPE增殖区域，发现血源性细胞存在于 Bruch 膜以及大量增殖的RPE细胞中，这表明血源性细胞可能从脉络膜循环穿过Bruch膜和RPE层。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/f82e88df1b3e/brjopthal00237-0020-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/38fba3a3cfc0/brjopthal00237-0015-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/fa728ddc5628/brjopthal00237-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/7ed9332ffd15/brjopthal00237-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/1d3a864fdddb/brjopthal00237-0018-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/7ed9332ffd15/brjopthal00237-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/1d3a864fdddb/brjopthal00237-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/3f686993b4ee/brjopthal00237-0018-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/bb8fb0fa4c47/brjopthal00237-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/b79217a33827/brjopthal00237-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/1043049/f82e88df1b3e/brjopthal00237-0020-a.jpg

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