Noebels J L, Roth W T, Kopell B S
J Neurol Sci. 1978 Jun;37(1-2):51-8. doi: 10.1016/0022-510x(78)90227-7.
In a group of 7 congenitally blind adults, electroencephalographic occipital alpha rhythms were absent, but slow negative cortical potentials (CNV) were recorded over the visual cortex and were similar to those of normally sighted controls. Frontal and central CNV amplitudes, but not auditory evoked potentials or reaction times, were decreased significantly in the blind. The results confirm the presence of a developmental EEG abnormality following early blindness, and demonstrate the independance of slow potential generation from rhythmic 8--12 c/sec EEG activity in deafferented visual cortex. Non-sensory specific, event-related potentials such as the Contingent Negative Variation may prove to be useful psychophysiological probes of residual cortical function in brain regions which are deprived of primary sensory input.
在一组7名先天性失明的成年人中，脑电图枕叶α节律缺失，但在视觉皮层记录到了缓慢的负性皮层电位（CNV），且与正常视力对照组的相似。盲人的额叶和中央CNV振幅显著降低，但听觉诱发电位或反应时间未受影响。结果证实早期失明后存在发育性脑电图异常，并表明在去传入视觉皮层中，缓慢电位的产生独立于8 - 12次/秒的节律性脑电图活动。非感觉特异性的事件相关电位，如关联性负变，可能被证明是对缺乏初级感觉输入的脑区残余皮层功能进行心理生理学探测的有用工具。
