Tamaki N, Harada M, Hama T
J Nutr Sci Vitaminol (Tokyo). 1978;24(3):279-87. doi: 10.3177/jnsv.24.279.
Anserine and carnosine in the muscle of growing rats were measured to explore the effect of dietary methionine. Carnosine was reduced in the gastrocnemius muscle of rats fed on a methionine-free diet. After refeeding on methionine for one week, carnosine in the muscle approached to the normal level. In contrast, anserine increased in the muscle of rats fed on a methionine-free diet. Anserine also increased in the gastrocnemius muscle of rats fed on a methionine-excess diet, whereas carnosine did not vary. Npi-Methylhistidine was detected in the muscle of rats fed on a methionine-excess diet. Moreover, Npi-methylhistindine and Ntau-methylhistine in the urine increased in the rats fed on both methionine-excess and methionine-free diets. Carnosine in the gastrocnemius muscle was not affected by a ethionine diet nor by a orotic acid diet which induced fatty liver. However, anserine increased in the muscle of rats fed on a ethionine diet.
检测了生长中大鼠肌肉中的鹅肌肽和肌肽，以探究膳食蛋氨酸的影响。在喂食无蛋氨酸饮食的大鼠腓肠肌中，肌肽减少。重新喂食蛋氨酸一周后，肌肉中的肌肽接近正常水平。相比之下，喂食无蛋氨酸饮食的大鼠肌肉中鹅肌肽增加。在喂食过量蛋氨酸饮食的大鼠腓肠肌中，鹅肌肽也增加，而肌肽没有变化。在喂食过量蛋氨酸饮食的大鼠肌肉中检测到N-甲基组氨酸。此外，在喂食过量蛋氨酸饮食和无蛋氨酸饮食的大鼠中，尿液中的N-甲基组氨酸和N-τ-甲基组氨酸均增加。腓肠肌中的肌肽不受乙硫氨酸饮食的影响，也不受诱导脂肪肝的乳清酸饮食的影响。然而，喂食乙硫氨酸饮食的大鼠肌肉中鹅肌肽增加。
