Miyama A, Kawamoto Y, Ichikawa H, Moriyama T, Okamoto K, Takahashi T
Microbiol Immunol. 1981;25(2):195-203. doi: 10.1111/j.1348-0421.1981.tb00022.x.
A kinetic study of factor B secretion by particle-ingesting macrophages showed that the ingestion of zymosan but not latex lead to an early suppression of factor B secretion followed by a significant enhancement. This dual response was proportional to the number of ingested zymosans. After a suppressive period of 24-48 hr, the ingested zymosan stimulated the synthesis of factor B. The response of acid phosphatase synthesis to ingested zymosan was the same as that of factor B, while the synthesis of lactic dehydrogenase proceeded without an early suppression. These results suggest that factor B should be considered an enzyme released into the lysosomes of macrophages.
一项关于吞噬颗粒的巨噬细胞分泌B因子的动力学研究表明，吞噬酵母聚糖而非乳胶会导致B因子分泌早期受到抑制，随后显著增强。这种双重反应与吞噬的酵母聚糖数量成正比。在24 - 48小时的抑制期后，摄入的酵母聚糖刺激了B因子的合成。酸性磷酸酶合成对摄入酵母聚糖的反应与B因子相同，而乳酸脱氢酶的合成则没有早期抑制。这些结果表明，B因子应被视为释放到巨噬细胞溶酶体中的一种酶。
