兔血浆激肽释放酶由补体第五成分产生的趋化活性。
Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit.
作者信息
Wiggins R C, Giclas P C, Henson P M
出版信息
J Exp Med. 1981 Jun 1;153(6):1391-404. doi: 10.1084/jem.153.6.1391.
Abstract
Rabbit plasma kallikrein incubated with rabbit C5 resulted in the generation of chemotactic and secretagogue activity for rabbit neutrophils. This effect on C5 appeared to be due to kallikrein itself and not to a contaminating enzyme, because it could be inhibited by anti-kallikrein IgG or by soybean trypsin inhibitor to the same extent the kinin generation by the same kallikrein preparation was inhibited by these agents. The chemotactic response was consistent with the generation of a C5a-like peptide from C5 because the effect could be partially inhibited by carboxypeptidase N and was related to the generation of a small (approximately 14,000 mol wt) fragment of C5. No direct chemotactic response was detectable for kallikrein, activated Hageman factor, high-molecular weight kininogen, or intact C5. Incubation of Kallikrein, high-molecular weight kininogen, and Hageman factor together, so that activation of all three proteins occurred, did not results in the generation of detectable chemotactic activity.
摘要
兔血浆激肽释放酶与兔C5一起孵育，会产生对兔中性粒细胞的趋化活性和促分泌活性。对C5的这种作用似乎是由于激肽释放酶本身，而非污染性酶，因为它可被抗激肽释放酶IgG或大豆胰蛋白酶抑制剂抑制，抑制程度与这些试剂对同一激肽释放酶制剂产生激肽的抑制程度相同。趋化反应与从C5生成C5a样肽一致，因为该作用可被羧肽酶N部分抑制，且与C5的一个小片段（约14,000道尔顿分子量）的生成有关。对于激肽释放酶、活化的哈格曼因子、高分子量激肽原或完整的C5，未检测到直接的趋化反应。将激肽释放酶、高分子量激肽原和哈格曼因子一起孵育，使所有三种蛋白质都被激活，并未产生可检测到的趋化活性。
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