哈格曼因子（凝血因子XII）对中性粒细胞运动和趋化性的意义。
Significance of Hageman factor (coagulation factor XII) for neutrophil locomotion and chemotaxis.
作者信息
Keller H U, Beck E A, Hess M W, Cottier H
出版信息
Int Arch Allergy Appl Immunol. 1977;55(1-6):309-13. doi: 10.1159/000231941.
PMID:591099
Abstract
Neutrophils separated from Hageman factor-deficient blood exhibit normal random and directional locomotion. No defect in cytotaxin formation could be demonstrated in Hageman factor-deficient plasma, nor did kallikrein inhibitor interfere with the chemotactic activity of normal immune complex-activated human plasma. The results suggest that the chemotactic activity which is detectable in unfractionated human plasma is not derived from Hageman factor-dependent pathways.
摘要
从缺乏哈格曼因子的血液中分离出的中性粒细胞表现出正常的随机运动和定向运动。在缺乏哈格曼因子的血浆中未发现细胞趋化素形成存在缺陷，激肽释放酶抑制剂也未干扰正常免疫复合物激活的人血浆的趋化活性。结果表明，在未分级的人血浆中可检测到的趋化活性并非源自依赖哈格曼因子的途径。
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