离体大鼠肾脏释放地塞米松、醛固酮和激肽释放酶

Dexamethasone, aldosterone and kallikrein release by isolated rat kidney.

Vio C P, Roblero J S, Croxatto H R

Clin Sci (Lond). 1981 Aug;61(2):241-3. doi: 10.1042/cs0610241.

Abstract

The effect of D-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. 2. Animals received D-aldosterone or dexamethasone (10 microgram/100 g body weight) daily for 3 days. Their isolated kidneys were then perfused with the same steroids at rates of 2.0-2.5 microgram/min for 30 min. 3. Dexamethasone increased kallikrein release significantly (P less than 0.001) both in urine and in venous outflow. 4. D-Aldosterone had no significant effect on kallikrein release, either in urine or in venous outflow.

摘要

在灌注改良克氏-亨氏缓冲液的离体大鼠肾脏中，研究了D-醛固酮和地塞米松对激肽释放酶释放的影响。2. 动物连续3天每天接受D-醛固酮或地塞米松（10微克/100克体重）。然后将它们的离体肾脏用相同的类固醇以2.0 - 2.5微克/分钟的速率灌注30分钟。3. 地塞米松显著增加了尿液和静脉流出液中激肽释放酶的释放（P小于0.001）。4. D-醛固酮对尿液或静脉流出液中激肽释放酶的释放没有显著影响。