Gunning R R, Garber A J
JAMA. 1978 Oct 6;240(15):1611-2.
The efficacy of instant glucose as a potential treatment for hypoglycemia was studied in normal volunteers, with therapeutic doses administered in the buccal cavity. 2-Tritiated glucose (50 mu Ci) was homogenized into each dose before use. Mean blood glucose and serum insulin concentrations were unaltered by instant glucose. Glucose absorption was less than 0.05 mg at any time, and total glucose absorbed was less than 0.1 mg. For comparison purposes, volunteers swallowed a dose of instant glucose. Approximately 88% of the dose was absorbed during a 30-minute interval. Blood glucose and insulin levels increased. Instant glucose appears to be of therapeutic value only if swallowed by fully conscious, hypoglycemic patients. It should not benefit unconscious patients because of its poor absorption through the buccal mucosa.
在正常志愿者中研究了速溶葡萄糖作为低血糖潜在治疗方法的疗效，治疗剂量经口腔给药。使用前将2-氚标记葡萄糖（50微居里）均匀混入每个剂量中。速溶葡萄糖对平均血糖和血清胰岛素浓度无影响。在任何时候葡萄糖吸收量均小于0.05毫克，总吸收葡萄糖量小于0.1毫克。为作比较，志愿者吞服一剂速溶葡萄糖。在30分钟内约88%的剂量被吸收。血糖和胰岛素水平升高。速溶葡萄糖似乎只有被完全清醒的低血糖患者吞服才有治疗价值。由于其经颊黏膜吸收不佳，对昏迷患者无益处。
