Meyers J D, Stamm W E, Kerr M M, Counts G W
JAMA. 1978 Oct 13;240(16):1725-7.
An orthopedic surgeon in whom hepatitis B subsequently developed participated in operations on 49 patients in the two months preceding his illness. Thirty of these patients were available for subsequent clinical and serologic follow-up: five had positive reactions for antibody to hepatitis B surface antigen (anti-HBs) and one had a positive reaction for hepatitis B surface antigen (HBsAg) at the initial examination an average of 77 days after surgery. No new patients had either clinical or serologic evidence of hepatitis B during four months of subsequent follow-up (mean of 6.7 months after surgery). A control group of 56 orthopedic patients had a 25% prevalence of positive reactions for anti-HBs and negative reactions for HBsAg- this was not significantly different from the exposed group. The risk to patients of acquiring hepatitis B after surgical exposure in this setting from a surgeon is low.
一名随后患上乙型肝炎的骨科医生在其患病前两个月为49名患者进行了手术。其中30名患者可供后续进行临床和血清学随访：5名患者在术后平均77天的初次检查时乙肝表面抗原抗体（抗-HBs）反应呈阳性，1名患者乙肝表面抗原（HBsAg）反应呈阳性。在随后四个月的随访中（术后平均6.7个月），没有新患者出现乙肝的临床或血清学证据。一个由56名骨科患者组成的对照组抗-HBs反应呈阳性且HBsAg反应呈阴性的比例为25%，这与暴露组没有显著差异。在这种情况下，患者因手术接触该外科医生而感染乙型肝炎的风险较低。
