Toxicity of penicillamine. A serious limitation to therapy in rheumatoid arthritis.
作者信息
Halverson P B, Kozin F, Bernhard G C, Goldman A L
出版信息
JAMA. 1978 Oct 20;240(17):1870-2. doi: 10.1001/jama.240.17.1870.
PMID:691197
Abstract
A retrospective study of penicillamine toxicity in 156 patients yielded a high incidence of toxic reaction (62%), necessitating discontinuation of the drug therapy in 36% of the patients. Of the total group, proteinuria occurred in 14%, hematologic toxic reaction in 11%, mucocutaneous toxic reaction in 28%, and gastrointestinal intolerance in 12%.
摘要
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