Vozeh S, Powell J R, Riegelman S, Costello J F, Sheiner L B, Hopewell P C
JAMA. 1978 Oct 20;240(17):1882-4.
Three patients demonstrated twofold to threefold changes in total-body theophylline clearance during the course of a single hospitalization for an acute illness. These changes paralleled the changes in the patients' clinical status. Theophylline clearance decreased in one patient with worsening airway obstruction, whereas clearance increased in one patient with resolving pneumonia and in one patient with improving congestive heart failure. Total-body theophylline clearance may be unstable in acute, severe illness. Close monitoring of plasma theophylline concentration in such situations will allow appropriate dose adjustments to be made and is, therefore, indicated.
三名患者在因急性疾病单次住院期间，其全身茶碱清除率出现了两倍至三倍的变化。这些变化与患者的临床状况变化相一致。一名气道阻塞加重的患者，其茶碱清除率降低；而一名肺炎好转的患者和一名充血性心力衰竭改善的患者，其清除率升高。在急性重症疾病中，全身茶碱清除率可能不稳定。在这种情况下密切监测血浆茶碱浓度，将有助于进行适当的剂量调整，因此是必要的。
