Vozeh S, Kewitz G, Wenk M, Follath F
Eur J Clin Pharmacol. 1980 Nov;18(6):473-7. doi: 10.1007/BF00874658.
In 15 acutely ill asthmatics the steady-state serum theophylline concentration was predicted by the method of Chiou et al. using two serum concentration measurements obtained 1 and 5 h after starting a continuous infusion of aminophylline. Two theophylline assays with different precision characteristics were compared. With a precise HPLC-assay the prediction was excellent: prediction error (predicted minus measured concentration) = -0.22 +/- 1.97 mg/l (mean +/- SD); r = 0.922. When the theophylline concentration was determined by a rapid enzyme immunoassay of lower precision, but convenient for clinical use, the prediction was less accurate (prediction error = 0.58 +/- 3.88, r = 0.852). However, it was still clearly superior to dosing recommendations based on the population average of theophylline clearance, even after taking into consideration the effect of smoking, congestive heart failure and cirrhosis (prediction error = 3.62 +/- 13.36, r = 0.560). As employed in this study, the method may be useful in helping the physician to choose the optimal dose in severely ill asthmatics.
在15例急性哮喘患者中，采用邱氏等人的方法，通过在持续输注氨茶碱开始后1小时和5小时获得的两次血清浓度测量值，预测稳态血清茶碱浓度。比较了两种具有不同精密度特征的茶碱测定方法。使用精确的高效液相色谱法测定时，预测效果极佳：预测误差（预测浓度减去实测浓度）=-0.22±1.97mg/L（均值±标准差）；r=0.922。当通过精密度较低但临床使用方便的快速酶免疫法测定茶碱浓度时，预测准确性较差（预测误差=0.58±3.88，r=0.852）。然而，即使考虑吸烟、充血性心力衰竭和肝硬化的影响，该方法仍明显优于基于茶碱清除率人群平均值的给药建议（预测误差=3.62±13.36，r=0.560）。本研究中所采用的方法可能有助于医生为重症哮喘患者选择最佳剂量。
