Esteller A, Jiminez R, Lopez M A
Q J Exp Physiol. 1981 Oct;66(4):359-65. doi: 10.1113/expphysiol.1981.sp002579.
The biliary response to feeding has been investigated in intact and cholecystectomized rabbits, with and without interruption of the enterohepatic circulation of bile salts. The relative contribution of the different secretory mechanisms involved in this process has been examined. Feeding induced an increase in the flow and bicarbonate concentration of the bile and a slight decrease in the bile salt content in rabbits with gall bladders and the enterohepatic circulation intact. Feeding with the enterohepatic circulation interrupted elicited a drop in bile flow and the bile salt concentration, but an increase in bicarbonate concentration. Interruption of the enterohepatic circulation thus dramatically modifies the feeding response: a response to food is still detectable after interruption, but is masked by the negative effects of drainage of the bile away from the duodenum.
在完整的和已切除胆囊的兔子中，研究了胆汁对进食的反应，同时考虑了胆汁盐肝肠循环是否中断的情况。已对该过程中涉及的不同分泌机制的相对作用进行了研究。在胆囊和肝肠循环均完整的兔子中，进食会导致胆汁流量和碳酸氢盐浓度增加，胆汁盐含量略有下降。在肝肠循环中断的情况下进食，会引起胆汁流量和胆汁盐浓度下降，但碳酸氢盐浓度会增加。因此，肝肠循环的中断会显著改变进食反应：中断后对食物的反应仍可检测到，但被胆汁从十二指肠引流的负面影响所掩盖。
