Esteller A, Jiminez R, Lopez M A
Q J Exp Physiol. 1981 Oct;66(4):349-57. doi: 10.1113/expphysiol.1981.sp002578.
The role of enterohepatic circulation of bile salts in biliary secretion in conscious rabbits has been investigated before and after cholecystectomy. Bile flow was higher and bile salt concentration lower in cholecystectomized than in intact rabbits: this could have been caused by a negative feed-back effect on bile salt synthesis as the circulating bile salt pool increased. The effects of cholecystectomy on flow and bile salt concentration balanced each other. Bile flow and bile salt concentration declined after interruption of the enterohepatic circulation in both cholecystectomized and intact rabbits. Furthermore, the percentage of the flow of bile independent of bile salt secretion increased, while that independent of total analysed solutes decreased after the enterohepatic circulation was broken. These results confirm that the decrease in bile flow after interruption of the enterohepatic circulation is due to loss of bile salts and not of electrolytes.
在有意识的兔子身上，已经研究了胆囊切除术前和术后胆盐的肠肝循环在胆汁分泌中的作用。胆囊切除术后的胆汁流量比完整兔子的更高，而胆盐浓度更低：这可能是由于随着循环胆盐池的增加，对胆盐合成产生了负反馈效应。胆囊切除术对胆汁流量和胆盐浓度的影响相互抵消。在胆囊切除的兔子和完整的兔子中，肠肝循环中断后，胆汁流量和胆盐浓度均下降。此外，肠肝循环中断后，不依赖胆盐分泌的胆汁流量百分比增加，而不依赖总分析溶质的胆汁流量百分比下降。这些结果证实，肠肝循环中断后胆汁流量的减少是由于胆盐的流失，而非电解质的流失。
