Ryerson G, Block E R, Harris J O, Cannon J K
Exp Lung Res. 1981 Nov;2(4):241-8. doi: 10.3109/01902148109052320.
Elastase-induced emphysema in hamsters was used as a model to determine whether this type of chronic lung injury affected the metabolic function of pulmonary endothelium. 5-Hydroxytryptamine (5-HT) uptake was studied in isolated perfused lungs of hamsters from a control group and from those with emphysema of various severity. After measuring 5-HT uptake, we determined the mean linear intercept and internal surface area for each lung. The concentration of 5-HT used in the perfusate ranged from the level in the resting hamster to supraphysiologic levels. The results reveal that elastase-induced emphysema does not affect 5-HT uptake by the isolated perfused hamster lung despite significant loss of alveolar surface area.
用弹性蛋白酶诱导的仓鼠肺气肿作为模型，以确定这种类型的慢性肺损伤是否会影响肺内皮的代谢功能。在来自对照组以及患有不同严重程度肺气肿的仓鼠的离体灌注肺中研究了5-羟色胺（5-HT）摄取。在测量5-HT摄取后，我们测定了每只肺的平均线性截距和内表面积。灌注液中使用的5-HT浓度范围从静息仓鼠体内的水平到超生理水平。结果显示，尽管肺泡表面积显著减少，但弹性蛋白酶诱导的肺气肿并不影响离体灌注的仓鼠肺对5-HT的摄取。
