Fujimoto M, Yamanaka T, Bessho M, Igarashi T
Eur J Pharmacol. 1982 Jan 22;77(2-3):113-8. doi: 10.1016/0014-2999(82)90004-8.
The effects of geranylgeranylacetone (GGA), a new acyclic polyisoprenoid with a novel antiulcer action on gastrointestinal secretion were studied in rats. Intraduodenal administration of GGA (1-30 mg/kg) dose-relatedly reduced the gastric acid secretion caused by pentagastrin, histamine or insulin. On the other hand, GGA (3-30 mg/kg i.d.) dose-relatedly increased pancreatic secretion but did not affect biliary secretion. The above-mentioned findings seem consistent with the further findings that GGA depressed a plasma gastrin level enhanced by insulin while in increased the basal level of plasma secretin. These pharmacological features found in the present studies may partially, at least, account for the mechanism of GGA antiulcer action.
研究了香叶基香叶基丙酮（GGA），一种具有新型抗溃疡作用的无环多异戊二烯，对大鼠胃肠分泌的影响。十二指肠内给予GGA（1-30mg/kg）剂量依赖性地减少了由五肽胃泌素、组胺或胰岛素引起的胃酸分泌。另一方面，GGA（3-30mg/kg十二指肠内给药）剂量依赖性地增加了胰腺分泌，但不影响胆汁分泌。上述发现似乎与进一步的发现一致，即GGA降低了胰岛素增强的血浆胃泌素水平，同时增加了血浆促胰液素的基础水平。本研究中发现的这些药理学特性可能至少部分解释了GGA抗溃疡作用的机制。
