西咪替丁对大鼠基础胃酸分泌的影响。
The effect of cimetidine on basal gastric acid secretion in the rat.
作者信息
Broughton N S, Morris J F
出版信息
Br J Pharmacol. 1982 Aug;76(4):551-5. doi: 10.1111/j.1476-5381.1982.tb09253.x.
Abstract
- The effect of cimetidine on the basal gastric acid secretion of the rat has been investigated in an anaesthetized lumen-perfused preparation. 2. Six rats previously given large doses of cimetidine orally showed no significant difference in basal gastric acid secretion when compared with six control rats. 3. Intravenous administration of 1 mg and 8 mg of cimetidine failed to inhibit significantly basal gastric acid secretion. 4. Although rats with a basal gastric acid secretion above 2.5 micro Eq/10 min. showed a consistent small reduction in basal gastric acid secretion after intravenous cimetidine, this was not seen in rats with a basal gastric acid secretion below 2.5 micro Eq/10 min. 5. THese results contrast sharply with the pronounced inhibition of basal gastric acid secretion by cimetidine in man and the possible reasons for this are discussed. 6. The results are also contrasted with previous work on gastric fistula rats which showed higher basal gastric acid secretion and significant inhibition by cimetidine.
摘要
- 已在麻醉的肠腔灌注制备物中研究了西咪替丁对大鼠基础胃酸分泌的影响。2. 六只先前口服大剂量西咪替丁的大鼠与六只对照大鼠相比，基础胃酸分泌无显著差异。3. 静脉注射1毫克和8毫克西咪替丁未能显著抑制基础胃酸分泌。4. 尽管基础胃酸分泌高于2.5微当量/10分钟的大鼠在静脉注射西咪替丁后基础胃酸分泌持续出现小幅下降，但基础胃酸分泌低于2.5微当量/10分钟的大鼠未出现这种情况。5. 这些结果与西咪替丁对人体基础胃酸分泌的显著抑制形成鲜明对比，并讨论了其可能的原因。6. 这些结果也与先前对胃瘘大鼠的研究结果形成对比，先前的研究显示胃瘘大鼠基础胃酸分泌较高且西咪替丁有显著抑制作用。
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Br J Pharmacol. 1982 Aug;76(4):551-5. doi: 10.1111/j.1476-5381.1982.tb09253.x.
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