Tachibana I, Watanabe N, Shirohara H, Akiyama T, Nanano S, Otsuki M
Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Int J Pancreatol. 1995 Apr;17(2):147-54. doi: 10.1007/BF02788532.
The effects of tetraprenylacetone (TPN), an acyclic polyisoprenoid with antiulcer actions, on pancreatic exocrine secretion, and its preventive and therapeutic effects on acute pancreatitis in two experimental models were studied in rats. Intraduodenal administration of TPN (0, 100, 200, and 400 mg/kg/h) caused dose-dependent increases in pancreatic juice and bicarbonate output without increasing protein output and plasma cholecystokinin (CCK) concentrations. TPN-stimulated pancreatic exocrine secretion was completely abolished by antisecretin serum but it was not by CCK receptor antagonist loxiglumide (50 mg/kg/h). In acute pancreatitis induced by four subcutaneous injections of 20 micrograms/kg cerulein at hourly intervals over, 3 h, TPN (400 mg/kg) given by an oral route either 1 h before the first cerulein injection or immediately after the last injection significantly reduced the increases in serum amylase and lipase activities and pancreatic wet wt. Pretreatment with TPN caused histologic improvements, whereas posttreatment failed to ameliorate histologic alterations. In severe type of acute pancreatitis induced by retrograde intraductal injection of 1.0 mL/kg of 4% sodium taurocholate, TPN exerted no apparent beneficial effects on biochemical and histologic alterations of acute pancreatitis. It is concluded that TPN given by an oral route stimulates pancreatic exocrine secretion through an increase in endogenous secretin release and causes beneficial effects on the experimental model of mild acute pancreatitis in rats.
研究了具有抗溃疡作用的无环多聚异戊二烯类化合物异戊烯基丙酮（TPN）对大鼠胰腺外分泌的影响及其在两种实验模型中对急性胰腺炎的预防和治疗作用。十二指肠内给予TPN（0、100、200和400mg/kg/h）可使胰液和碳酸氢盐分泌量呈剂量依赖性增加，而不会增加蛋白质分泌量和血浆胆囊收缩素（CCK）浓度。抗促胰液素血清可完全消除TPN刺激的胰腺外分泌，但CCK受体拮抗剂洛谷酰胺（50mg/kg/h）则不能。在通过每小时皮下注射20μg/kg雨蛙素共3小时诱导的急性胰腺炎中，在首次注射雨蛙素前1小时或最后一次注射后立即口服给予TPN（400mg/kg）可显著降低血清淀粉酶和脂肪酶活性以及胰腺湿重的增加。TPN预处理可改善组织学变化，而治疗后未能改善组织学改变。在通过逆行胰管内注射1.0mL/kg 4%牛磺胆酸钠诱导的重症急性胰腺炎中，TPN对急性胰腺炎的生化和组织学改变无明显有益作用。结论是口服TPN通过增加内源性促胰液素释放来刺激胰腺外分泌，并对大鼠轻度急性胰腺炎实验模型产生有益作用。
