Bach T J, Lichtenthaler H K
Z Naturforsch C Biosci. 1982 Jan-Feb;37(1-2):46-50. doi: 10.1515/znc-1982-1-209.
The fungal metabolite mevinolin, known to be a potent hypocholesterolemic agent, exerts in vitro a strong inhibitory effect on microsomal HMG-CoA reductase from etiolated radish seedlings at a concentration of about three magnitudes lower than the Km towards the natural substrate (S)-HMG-CoA (I50 = 2.5 x 10(-9)M). Beside this, mevinolin significantly inhibits the root elongation of radish as well as of wheat seedlings already at low concentrations of 10 to 100 ppb (= 2.5 x 10(-8) to 2.5 x 10(-7)M).
真菌代谢产物美伐他汀是一种有效的降胆固醇药物，在体外，它对黄化萝卜幼苗微粒体HMG-CoA还原酶具有很强的抑制作用，其浓度比天然底物（S）-HMG-CoA的Km低约三个数量级（I50 = 2.5×10^(-9)M）。除此之外，美伐他汀在10至100 ppb（= 2.5×10^(-8)至2.5×10^(-7)M）的低浓度下就能显著抑制萝卜和小麦幼苗的根伸长。
