Myers J P, Linnemann C C
J Infect Dis. 1982 Apr;145(4):532-6. doi: 10.1093/infdis/145.4.532.
During a three-year period, Staphylococcus aureus phage type D11/83A/85 that was resistant to methicillin, cephalothin, and multiple aminoglycosides was recovered from 260 infected patients in an urban general hospital in Cincinnati, Ohio. This methicillin-resistant S. aureus (MRSA) was recovered from 30% of all blood cultures positive for S. aureus and represented 50% of all episodes of nosocomial bacteremia due to S. aureus. Bacteremia due to MRSA occurred most often in surgical patients (especially burn patients), occurred late in hospitalization, and was recovered frequently from wounds and intravascular catheters. Infection with S. aureus was the direct cause of death of 44% of the patients with bacteremia due to MRSA. Nine of 10 MRSA-infected patients who were treated with vancomycin alone responded to therapy compared with seven of 15 who were treated with other antistaphylococcal antibiotics (P less than 0.05). The present study defines the epidemiologic characteristics of bacteremia due to MRSA, demonstrates the virulence of MRSA, and proves that vancomycin is effective as therapy.
在三年期间，从俄亥俄州辛辛那提市一家城市综合医院的260名感染患者中分离出了对甲氧西林、头孢噻吩和多种氨基糖苷类耐药的金黄色葡萄球菌噬菌体D11/83A/85型。这种耐甲氧西林金黄色葡萄球菌（MRSA）从所有金黄色葡萄球菌血培养阳性结果的30%中分离得到，占所有金黄色葡萄球菌医院获得性菌血症病例的50%。MRSA引起的菌血症最常发生在外科患者（尤其是烧伤患者）中，在住院后期出现，并且经常从伤口和血管内导管中分离得到。金黄色葡萄球菌感染是44%的MRSA菌血症患者的直接死亡原因。单独使用万古霉素治疗的10例MRSA感染患者中有9例对治疗有反应，而使用其他抗葡萄球菌抗生素治疗的15例患者中有7例有反应（P<0.05）。本研究确定了MRSA菌血症的流行病学特征，证明了MRSA的毒力，并证实万古霉素作为治疗药物是有效的。
