用脂质体包裹的葡糖脑苷脂：β-葡萄糖苷酶治疗戈谢病。
Treatment of Gaucher's disease with liposome-entrapped glucocerebroside: beta-glucosidase.
作者信息
Belchetz P E, Crawley J C, Braidman I P, Gregoriadis G
出版信息
Lancet. 1977 Jul 16;2(8029):116-7. doi: 10.1016/s0140-6736(77)90123-4.
PMID:69198
Abstract
An adult with Gaucher's disease was injected with liposomes containing human glucocerebroside: beta-glucosidase. After 13 months of treatment the lower border of the right hepatic lobe and moved up 3 cm, and the left lobe had shrunk. Reduction in the size of the liver was associated with relief of pressure symptoms in the left lower abdomen. Scans obtained after the injection of radiolabelled liposomes suggested improvement in function of the reticuloendothelial system.
摘要
一名患有戈谢病的成年人被注射了含有人类葡萄糖脑苷脂
β-葡萄糖苷酶的脂质体。经过13个月的治疗，右肝叶下缘上移了3厘米，左叶缩小。肝脏大小的缩小与左下腹压力症状的缓解相关。注射放射性标记脂质体后获得的扫描结果表明网状内皮系统功能有所改善。
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