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大鼠母体膳食脂肪摄入与胎儿肺成熟的观察

Observations on maternal dietary fat intake and fetal pulmonary maturation in rats.

作者信息

Nelson G H, McPherson J, Perling L

出版信息

J Reprod Med. 1982 Jun;27(6):331-2.

PMID:6922185
Abstract

Pregnant rats were maintained on one of the following dietary regimes: (1) low fat through gestation; (2) low fat to gestational age 15, then high fat until term; or (3) high fat throughout gestation. Fetal pulmonary maturation (as measured by the lung content of acetone-precipitable lecithin) was accelerated in rats on the high-fat diet, was intermediate in the group on low fat later switched to high fat and was retarded in rats on the low-fat diet. We feel that these data, as well as previous reports from our laboratory, justify additional experiments on human subjects.

摘要

怀孕大鼠维持以下饮食方案之一

(1) 整个孕期低脂饮食;(2) 孕龄15周前低脂饮食,之后高脂饮食直至足月;或(3) 整个孕期高脂饮食。高脂饮食组大鼠的胎儿肺成熟(通过丙酮可沉淀卵磷脂的肺含量衡量)加快,先低脂后高脂组大鼠的胎儿肺成熟处于中间水平,低脂饮食组大鼠的胎儿肺成熟则延迟。我们认为,这些数据以及我们实验室之前的报告,证明有必要对人类受试者进行更多实验。

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