接受人α干扰素治疗的患者外周血单核细胞吞噬活性降低。
Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha.
作者信息
Einhorn S, Jarstrand C
出版信息
Cancer Immunol Immunother. 1982;13(3):149-52. doi: 10.1007/BF00205379.
Abstract
The influence of daily intramuscular injections of 3 X 10(6) units of interferon-alpha (IFN-alpha) on the phagocytic activity of peripheral monocytes was studied in 28 tumor patients. One day after initiation of IFN therapy no major change in the capacity of monocytes to ingest yeast particles was observed. After 1 week, 3 months, 6 months, and 9 months of treatment, monocyte phagocytosis had decreased in the majority of the patients tested. In patients where natural killer (NK) cell activity was measured simultaneously with monocyte phagocytosis, a correlation between the degree of enhancement of NK activity and the degree of decrease in monocyte phagocytosis was observed.
摘要
在28例肿瘤患者中研究了每日肌肉注射3×10⁶单位α-干扰素（IFN-α）对外周血单核细胞吞噬活性的影响。开始IFN治疗1天后，未观察到单核细胞摄取酵母颗粒能力的重大变化。治疗1周、3个月、6个月和9个月后，大多数受试患者的单核细胞吞噬作用下降。在同时测定自然杀伤（NK）细胞活性和单核细胞吞噬作用的患者中，观察到NK活性增强程度与单核细胞吞噬作用降低程度之间存在相关性。
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