Blomgren H, Einhorn S
Int Arch Allergy Appl Immunol. 1981;66(2):173-8. doi: 10.1159/000232816.
Human interferon (IFN) was examined for its capacity to modify the phytohaemagglutinin (PHA)-triggered release of mitogenic factors (MF) from human lymphocytes in vitro. It was observed that the presence of partially purified leukocyte IFN (IFN-alpha) during the PHA pulsing of lymphocytes increased their subsequent release of factors which were mitogenic for fractionated T cells. A similar effect was also observed when lymphocytes were exposed to IFN-alpha prior to PHA pulsing. The possibility that substances in the IFN preparations other than IFN are responsible for the above effect is ruled out by the finding that a pure fibroblast IFN (IFN-beta) preparation also augmented the MF release by PHA-pulsed lymphocytes.
对人干扰素（IFN）在体外改变植物血凝素（PHA）触发的人淋巴细胞促有丝分裂因子（MF）释放的能力进行了检测。观察到，在淋巴细胞PHA脉冲处理期间存在部分纯化的白细胞干扰素（IFN-α），会增加其随后释放的对分离的T细胞有促有丝分裂作用的因子。当淋巴细胞在PHA脉冲处理之前暴露于IFN-α时，也观察到了类似的效果。纯成纤维细胞干扰素（IFN-β）制剂也增强了PHA脉冲处理的淋巴细胞的MF释放，这一发现排除了IFN制剂中除IFN之外的物质导致上述效应的可能性。
