Eadie M J, Heazlewood R, Tyrer J H
Clin Exp Neurol. 1981;18:123-31.
Simultaneous steady-state plasma levels of primidone and phenobarbitone were studied in 43 patients receiving primidone therapy. Primidone and phenobarbitone levels in the individual appeared to be linearly related but steady-state plasma phenobarbitone levels correlated better with primidone dose than did steady-state plasma levels of primidone itself. This pattern of correlation is probably due to primidone being more rapidly eliminated than the phenobarbitone that is derived from it. Steady-state plasma primidone levels showed more inter-dosage fluctuation than steady-state plasma phenobarbitone levels in the same patients. In the subjects studied age, sex, and concurrent anticonvulsant therapy did not alter the relation between plasma levels of primidone or phenobarbitone and primidone dose. The study suggested that knowledge of steady-state plasma primidone levels adds little to knowledge of plasma phenobarbitone levels in guiding the therapy of epilepsy with primidone.
对43例接受扑米酮治疗的患者，研究了扑米酮和苯巴比妥的稳态血浆水平。个体中扑米酮和苯巴比妥水平似乎呈线性相关，但稳态血浆苯巴比妥水平与扑米酮剂量的相关性比扑米酮自身的稳态血浆水平更好。这种相关模式可能是由于扑米酮比由其衍生的苯巴比妥消除得更快。在同一患者中，稳态血浆扑米酮水平比稳态血浆苯巴比妥水平表现出更大的剂量间波动。在所研究的受试者中，年龄、性别和同时进行的抗惊厥治疗并未改变扑米酮或苯巴比妥血浆水平与扑米酮剂量之间的关系。该研究表明，在指导扑米酮治疗癫痫时，了解稳态血浆扑米酮水平对了解血浆苯巴比妥水平帮助不大。
