Boysen M, Reith A
Ultrastruct Pathol. 1980 Oct-Dec;1(4):477-85. doi: 10.3109/01913128009140554.
Two different types of intracytoplasmic lumina have been observed electron microscopically in pseudostratified and metaplastic human nasal mucosa: one type contains microvilli and the other contains both microvilli and cilia. The latter type was seen only in pseudostratified columnar epithelium, while the former was also observed in different stages of metaplasia. From these observations we conclude that the type of intracytoplasmic lumina is determined by the differential potential of the cells in which they occur. Serial sectioning demonstrated that these structures sometimes communicate with the extracellular space. The distinctly different ultrastructure of microvilli lining the intracytoplasmic lumina and the foldlike extensions of the cell membrane favors an intracellular genesis rather than a formation by invagination of the cell membrane. It is suggested that intracytoplasmic lumina occur as a consequence of dysregulation in the process of epithelial maturation.
在假复层和化生的人鼻黏膜中，通过电子显微镜观察到了两种不同类型的胞质内管腔：一种类型含有微绒毛，另一种类型既含有微绒毛又含有纤毛。后一种类型仅见于假复层柱状上皮，而前一种类型在化生的不同阶段也可观察到。从这些观察结果我们得出结论，胞质内管腔的类型由其所在细胞的分化潜能决定。连续切片显示这些结构有时与细胞外间隙相通。胞质内管腔内衬的微绒毛与细胞膜的褶皱样延伸明显不同的超微结构，支持其为细胞内起源而非由细胞膜内陷形成。提示胞质内管腔是上皮成熟过程中调节异常的结果。
