锌人胰岛素（重组DNA）与锌猪胰岛素（慢胰岛素锌悬液）在年轻志愿者体内的时效曲线比较

Time-action profile of zinc human insulin (recombinant DNA) in young volunteers as compared with zinc porcine insulin (Monotard).

作者信息

Vander Hoogen F H, Hulst S G, Zweens J

出版信息

Diabetes Care. 1982 Nov-Dec;5 Suppl 2:71-2. doi: 10.2337/diacare.5.2.s71.

DOI:10.2337/diacare.5.2.s71

Abstract

Zinc human insulin (recombinant DNA) or zinc PPI (Monotard) 20 U was injected subcutaneously to study the time-action profile in six healthy volunteers. During the test period they received a 10-g biscuit containing 3% moisture, 7% protein, 10% fat, 80% carbohydrate, and 30 ml of water every hour. The onset of action with zinc human insulin occurred earlier than with zinc PPI. Also, the intensity of the blood sugar-lowering effect was more pronounced 3 and 4 h after administration of insulin. No other statistically significant differences were detected between the two blood glucose curves. The results show that it is possible to develop a zinc human insulin formulation with a duration of the blood sugar-lowering effect equal to a zinc PPI formulation.

摘要

皮下注射20单位的锌人胰岛素（重组DNA）或锌鱼精蛋白胰岛素（单时相胰岛素），以研究6名健康志愿者的时效曲线。在测试期间，他们每小时食用一块含有3%水分、7%蛋白质、10%脂肪、80%碳水化合物的10克饼干，并饮用30毫升水。锌人胰岛素的起效时间比锌鱼精蛋白胰岛素早。此外，胰岛素给药后3小时和4小时，降血糖作用的强度更为明显。两条血糖曲线之间未检测到其他统计学上的显著差异。结果表明，有可能开发出一种降血糖作用持续时间与锌鱼精蛋白胰岛素制剂相当的锌人胰岛素制剂。