Simon M A, Bos G D
J Bone Joint Surg Am. 1980 Mar;62(2):195-204.
In a restrospective macroscopic and microscopic study of twenty-six macrosections of skeletally immature individuals with metaphyseal osteosarcoma, we determined the incidence, extent, and mode of tumor extension into the epiphysis. The physis appeared to have a tendency to act as a barrier to tumor spread, but did not restrain the tumor tissue in most cases. Epiphyseal extension of the tumor tissue was massive in more than half of the cases, with tumor tissue abutting against the articular cartilage, and in one instance perforating it. Some tumors had a sizable extra-osseous component that extended around the physis beneath the perichondral ring and capsular structures into the ossific nucleus. These findings have important implications when limited surgery is performed for appendicular osteosarcoma.
在一项对26例骨骼未成熟的干骺端骨肉瘤个体的宏观和微观回顾性研究中，我们确定了肿瘤向骨骺扩展的发生率、范围和方式。生长板似乎有作为肿瘤扩散屏障的倾向，但在大多数情况下并不能限制肿瘤组织。超过半数病例中肿瘤组织向骨骺的扩展是广泛的，肿瘤组织紧邻关节软骨，有1例甚至穿透了关节软骨。一些肿瘤有相当大的骨外成分，在软骨膜环和关节囊结构下方围绕生长板延伸至骨化核。这些发现对于肢体骨肉瘤行局限性手术具有重要意义。
