Hamersky P A, Weimer A D, Taintor J F
Am J Orthod. 1980 Apr;77(4):368-78. doi: 10.1016/0002-9416(80)90103-7.
This study investigates the effect of an orthodontic force on pulpal respiration in the human premolar. The participants in this study required the removal of four first premolars for orthodontic treatment. After written consent was obtained, these teeth were used in the following manner. Randomly, the premolars on one side of the mouth were designated as experimental and the premolars on the opposing side served as controls. The four teeth were removed following a 3-day application of an orthodontic force. The pulp tissue was then extirpated and used for the investigation. A radioactively labeled carbon dioxide production system was used to evaluate the effect on pulpal respiration of the orthodontic force. It is thought that this method has been proved to provide a viable and sensitive biochemical analysis of tissue respiration on very small samples over short observation periods. The data were collected and prepared for statistical analysis. This investigation demonstrated that the pulp tissue respiration in seventeen subjects was depressed an average of 27% as a result of orthodontic force application. A positive correlation between the age of the participant and the amount of tissue respiratory depression was also demonstrated. It was therefore concluded that orthodontic forces of very short duration do cause biochemical and biologic pulpal tissue alterations and that orthodontic forces may be less biologically safe as the age of the patient increases.
本研究调查正畸力对人类前磨牙牙髓呼吸的影响。本研究的参与者因正畸治疗需要拔除四颗第一前磨牙。获得书面同意后，这些牙齿按以下方式使用。随机将口腔一侧的前磨牙指定为实验组，对侧的前磨牙作为对照组。在施加正畸力3天后拔除这四颗牙齿。然后摘除牙髓组织用于研究。使用放射性标记的二氧化碳产生系统来评估正畸力对牙髓呼吸的影响。据认为，这种方法已被证明能在短观察期内对非常小的样本进行可行且灵敏的组织呼吸生化分析。收集数据并准备进行统计分析。这项调查表明，由于施加正畸力，17名受试者的牙髓组织呼吸平均降低了27%。还证明了参与者的年龄与组织呼吸抑制量之间存在正相关。因此得出结论，持续时间非常短的正畸力确实会引起牙髓组织的生化和生物学改变，并且随着患者年龄的增加，正畸力在生物学上可能不太安全。
