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[食管浸润性癌所致贲门失弛缓症。临床病例及病理生理考量]

[Achalasia caused by infiltrating carcinoma of the esophagus. Clinical case and physiopathological considerations].

作者信息

Vincre G, Peri G, Galliera M, Vimercati M

出版信息

Minerva Chir. 1978 Sep 15;33(17):1109-14.

PMID:692894
Abstract

A case of symptomatic esophageal achalasia due to a slowly growing neoplastic infiltration of the esophageal wall by a mammary indifferentiated carcinoma operated ten years before is presented. At admission, the clinical history and the endoscopic appearance of the esophageal lumen and mucosa led to the diagnosis of idiopathic achalasia, while the esophageal manometry showed a rather long high pressure zone (6--8 cm), which did not relax with deglutition. Barium study confirmed the length of the achalasic tract. Only thoracotomy permitted a correct diagnosis. On the basis of this case achalasia is thus considered as a syndrome which can be either idiopathic or secondary to Trypanosoma cruzi, high troncular vagotomy, benign or malignant tumor infiltrating the esophageal wall. The difficult diagnosis of some cases from the clinical point of view is underlined. Stress is laid on the necessity that all findings (history, radiology, endoscopy, manometry) be carefully evaluated to reach a preoperative diagnosis.

摘要

本文报道了一例因十年前手术切除的乳腺未分化癌对食管壁进行缓慢生长的肿瘤浸润而导致的症状性食管贲门失弛缓症。入院时,临床病史以及食管腔和黏膜的内镜表现提示为特发性贲门失弛缓症,而食管测压显示存在相当长的高压区(6 - 8厘米),吞咽时并不松弛。钡餐检查证实了失弛缓段的长度。只有开胸手术才得以做出正确诊断。基于此病例,贲门失弛缓症被视为一种综合征,它既可以是特发性的,也可以继发于克氏锥虫感染、高位迷走神经切断术、良性或恶性肿瘤浸润食管壁。强调了从临床角度来看某些病例诊断困难的情况。着重指出必须仔细评估所有检查结果(病史、放射学、内镜检查、测压)以达成术前诊断。

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