Ling G N, Tucker M
J Natl Cancer Inst. 1980 May;64(5):1199-1207.
By studying nuclear magnetic resonance water proton spin-lattice relaxation times (T1 and T2) of normal mouse and rat tissues at varying water contents and by comparing the data with those obtained from five types of cancer cells in ascites form, we concluded that differences in total water contents between normal tissues and cancer cells contribute less than 10% to the differences between the longer T1 of cancer cells as compared to the T1 of normal tissues. In spite of the diverse origin of the five types of cancer cells studied, their T1 and T2 as well as water contents were confined within relatively narrow limits. We suggested that all 5 ascites tumors studied are maximally deviated and that the physical state of the water in all maximally deviated cancer cells is very similar.
通过研究正常小鼠和大鼠组织在不同含水量下的核磁共振水质子自旋晶格弛豫时间（T1和T2），并将数据与从五种腹水形式的癌细胞中获得的数据进行比较，我们得出结论，正常组织和癌细胞之间总含水量的差异对癌细胞T1比正常组织T1更长的差异贡献小于10%。尽管所研究的五种癌细胞起源不同，但其T1、T2以及含水量都局限在相对较窄的范围内。我们认为所研究的所有5种腹水肿瘤都处于最大偏离状态，并且所有最大偏离的癌细胞中水的物理状态非常相似。
