Kawashima K, Suzuki H, Yamada K, Kato Y, Watanabe E, Morishima Y, Takeyama H, Kobayashi M
Cancer. 1980 Apr 15;45(8):2181-7. doi: 10.1002/1097-0142(19800415)45:8<2181::aid-cncr2820450829>3.0.co;2-9.
In a national survey of five-year survivors with acute leukemia, 233 of 304 cases were children under 14 years of age and 71 were adults. There were 107 myeloblastic, 10 promyelocytic, 142 lymphocytic, and 37 undifferentiated leukemias, Forty-five cases at age 3 represented the peak. These long-term survivors have shown a yearly increase in number. In 1972, the number of childhood ALL cases reached 38 with no great changes in ANLL cases. With respect to prognosis among long-term survivors, it seemed that neither type of leukemia nor age at diagnosis were factors influencing the future survival. CNS relapse occurring before the third year was an unfavorable complication for a prognosis beyond five years. Only 8 patients died of leukemia among 155 patients who reached five years in their initial complete remission; 49 of 90 patients who had relapse within five years after diagnosis died of leukemia. From these findings, it seems very important to follow patients for five years in their initial complete remission.
在一项针对急性白血病五年幸存者的全国性调查中，304例病例中有233例是14岁以下的儿童，71例是成年人。其中有107例为粒细胞性白血病、10例早幼粒细胞性白血病、142例淋巴细胞性白血病和37例未分化白血病，3岁的病例有45例，为发病高峰。这些长期幸存者的数量逐年增加。1972年，儿童急性淋巴细胞白血病病例数达到38例，急性非淋巴细胞白血病病例数无太大变化。关于长期幸存者的预后，似乎白血病类型和诊断时的年龄都不是影响未来生存的因素。在第三年之前发生的中枢神经系统复发是影响五年以上预后的不良并发症。在最初完全缓解后存活五年的155例患者中，只有8例死于白血病；在诊断后五年内复发的90例患者中有49例死于白血病。从这些发现来看，在患者最初完全缓解后对其进行五年的随访似乎非常重要。
