Diwan B A, Blackman K E
J Natl Cancer Inst. 1980 Jun;64(6):1491-3. doi: 10.1093/jnci/64.6.1491.
Inbred mice of strains C57BL/6J (B6) (Ahb/-Ahb) and DBA/2J (D2) (Ahd/Ahd) were administered 3-methylcholanthrene (MCA) alone, 1,2-dimethylhydrazine (DMH) alone, and MCA and DMH together. Colorectal tumors were observed in 32% of the DMH-treated B6 mice, but no such tumors occurred in similarly treated D2 mice. Of the MCA-treated D2 mice, 46% were susceptible to leukemia, whereas in similarly treated B6 mice, 19% developed only lung tumors. The combined application of MCA and DMH resulted in an increased incidence of colorectal (52%) and lung (44%) tumors in B6 mice and, to some extent, of leukemia (63%) in D2 mice. The role of genetic background on the carcinogenic effects of combined application of MCA and DMH in inbred mice is discussed.
对C57BL/6J（B6）（Ahb/-Ahb）品系和DBA/2J（D2）（Ahd/Ahd）品系的近交系小鼠分别单独给予3-甲基胆蒽（MCA）、单独给予1,2-二甲基肼（DMH）以及同时给予MCA和DMH。在接受DMH处理的B6小鼠中，32%出现了结肠直肠肿瘤，但在接受类似处理的D2小鼠中未出现此类肿瘤。在接受MCA处理的D2小鼠中，46%易患白血病，而在接受类似处理的B6小鼠中，19%仅出现肺部肿瘤。MCA和DMH联合应用导致B6小鼠结肠直肠癌（52%）和肺癌（44%）的发病率增加，在一定程度上也导致D2小鼠白血病（63%）的发病率增加。本文讨论了遗传背景在近交系小鼠中MCA和DMH联合应用致癌作用中的作用。
