通过直肠内给予大鼠1,2 - 二甲基肼诱导结肠腺癌
Induction of colonic adenocarcinomas by 1,2-dimethylhydrazine intrarectally administered in rats.
作者信息
Markert C, Rogers L W, Chiu J F
出版信息
Digestion. 1978;18(3-4):261-5. doi: 10.1159/000198209.
PMID:738542
Abstract
Multiple colorectal adenocarcinomas were found in Sprague-Dawley rats after intrarectal injection of 1,2-dimethylhydrazine (DMH). These lesions along with mild hyperplasia of the surrounding mucosa developed within 34 weeks after either 3 or 8 injections of 250 mg DMH/kg body weight.
摘要
在向Sprague-Dawley大鼠直肠内注射1,2-二甲基肼（DMH）后，发现了多发性结肠腺癌。在以250毫克DMH/千克体重进行3次或8次注射后的34周内，这些病变连同周围黏膜的轻度增生一同出现。
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