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聚腺苷酸(poly(A))能否使信使核糖核酸前体的剪接位点对齐?

Could poly(A) align the splicing sites of messenger RNA precursors?

作者信息

Bina M, Feldmann R J, Deeley R G

出版信息

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1278-82. doi: 10.1073/pnas.77.3.1278.

Abstract

In general, poly(A)-mRNA appears to be derived from larger nuclear RNA precursors. The maturation of these precursors involves excision of sequences of variable length from within the molecule and splicing of the remaining structural and coding sequences. The mechanism by which this process occurs is not known. It does not appear to operate solely through the recognition of a defined primary sequence or through the formation of a consistent secondary structure. We propose an alternative model in which poly(A) facilitates the splicing event by promoting the formation of triple-stranded structures within the mRNA precursor.

摘要

一般来说,聚腺苷酸(poly(A))-mRNA似乎来源于更大的核RNA前体。这些前体的成熟涉及从分子内部切除可变长度的序列,以及剩余结构和编码序列的剪接。这个过程发生的机制尚不清楚。它似乎并非仅通过识别特定的一级序列或通过形成一致的二级结构来运作。我们提出了一种替代模型,其中聚腺苷酸通过促进mRNA前体中三链结构的形成来促进剪接事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b32/348477/a0c7deed416f/pnas00666-0056-a.jpg

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