Rogers J, Wall R
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1877-9. doi: 10.1073/pnas.77.4.1877.
The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.
真核细胞中最丰富的稳定小核RNA,即U-1小核RNA,与RNA剪接位点的共有序列完全互补。我们提出,这种RNA是核RNA剪接酶的识别成分,它与内含子的两端形成碱基对,以便将它们对齐进行切割和剪接。