Hermann C, Andersen E, Videbaek A
Scand J Haematol. 1980 Mar;24(3):234-6. doi: 10.1111/j.1600-0609.1980.tb01331.x.
A 60-year-old man with sarcoidosis of skin and knee joints was treated with prednisone and methotrexate (MTX). A total of 590 mg MTX was given over two periods each of 3 months duration. 4 1/2 years after the first MTX dose he developed acute myeloid leukaemia. Only one more case of acture myeloid leukaemia following MTX treatment for a benign disease has been described, and until further cases have been reported the correlation might be considered a matter of simple coincidence.
一名患有皮肤和膝关节结节病的60岁男性接受了泼尼松和甲氨蝶呤（MTX）治疗。在两个为期3个月的时间段内共给予590毫克MTX。首次服用MTX剂量4年半后，他患上了急性髓系白血病。在MTX治疗良性疾病后发生急性髓系白血病的病例仅另有一例被报道，在有更多病例报告之前，这种相关性可能被认为只是简单的巧合。
