Williams B, Francis A, Durrant S
Department of Haematology, Royal Brisbane Hospital, Herston, Queensland, Australia.
J Clin Pathol. 1994 Jul;47(7):672-3. doi: 10.1136/jcp.47.7.672.
A case of coexistent acute myeloid leukaemia and sarcoidosis is reported. This was complicated by recurrent pulmonary haemorrhage during reinduction and consolidation chemotherapy. A review of published papers on malignancy and sarcoidosis, in particular acute leukaemia is given. The outcome of most cases of acute leukaemia and sarcoidosis is poor with respiratory complications a frequent cause of death in this group. It is proposed that modifications to treatment to avoid pulmonary toxicity and maintenance of platelet counts above 40 x 10(9)/l are warranted to reduce the risk of this complication.
报告了一例急性髓系白血病与结节病并存的病例。该病例在再诱导和巩固化疗期间并发反复肺出血。本文对已发表的关于恶性肿瘤与结节病，特别是急性白血病的论文进行了综述。大多数急性白血病合并结节病病例的预后较差，呼吸并发症是该组患者常见的死亡原因。建议调整治疗方案以避免肺部毒性，并将血小板计数维持在40×10⁹/L以上，以降低这种并发症的风险。
