Palú G
Tumori. 1980 Feb;66(1):35-42. doi: 10.1177/030089168006600104.
Thymidine Phosphorylase activity has been measured in two populations of human Acute Myeloid Leukaemia cells (AML) and in normal human macrophages. During short-term culture in vitro of AML cells the activity of this enzyme increases progressively and approaches that of normal non-dividing macrophages at a time when the leukaemia cells in culture show evidence of maturation as assayed by functional, enzymatic and morphological criteria. It is suggested that the level of Thymidine Phosphorylase activity may be a marker of maturation in AML.
已在两组人类急性髓系白血病细胞（AML）以及正常人巨噬细胞中测量了胸苷磷酸化酶活性。在AML细胞的体外短期培养过程中，该酶的活性逐渐增加，当培养的白血病细胞根据功能、酶学和形态学标准显示出成熟迹象时，其活性接近正常非分裂巨噬细胞的活性。有人提出，胸苷磷酸化酶活性水平可能是AML成熟的一个标志物。
