Andrianova L F
Ontogenez. 1978;9(4):411-6.
A study of primary immunological response to the ram erythrocytes and response of primed CBA mice of different age has shown a sharp fall of the primary immunological response in senility. The young animals responded to the priming by the decrease of formation of direct antibody-forming cells in the spleen what is connected with the activation of suppressor cells. The response of primed animals increased with the age and attained in old mice the values markedly exceeding that of primary immunological response. In the system of syngeneic adoptive transfer of the spleen cells from the primed mice of different age, the response of recipients of young animal's cells was lower that of recipients of old animal's cells. The data obtained suggest the devrease of the suppressor activity of the primed spleen cells with the age.
一项关于对绵羊红细胞的初次免疫反应以及不同年龄的经致敏CBA小鼠的反应的研究表明，衰老过程中初次免疫反应急剧下降。年幼动物对致敏的反应是脾脏中直接抗体形成细胞的形成减少，这与抑制细胞的激活有关。经致敏动物的反应随年龄增加，在老年小鼠中达到明显超过初次免疫反应的值。在不同年龄经致敏小鼠的脾细胞同基因过继转移系统中，年幼动物细胞受体的反应低于老年动物细胞受体的反应。所获得的数据表明，经致敏的脾细胞的抑制活性随年龄降低。
