Anderson I L, Rawstron R E, Dunlop D J
N Z Med J. 1980 Jun 11;91(661):417-9.
In vitro pharmacological testing of isolated muscle strips surgically removed under general anaesthesia from 10 members of a known MH family enabled identification of three MH positive individuals. Diagnosis of MH susceptibility was based on increased sensitivity to low concentrations of caffeine and the presence of halothane-induced contractures in MH susceptible muscle. Dantrolene sodium 15 mg/l completely prevented halothane-induced contractures in two muscle strips from one of the MH positive cases. The successful anaesthetic management of known MH patients is described, as is the successful management of a hyperthermic episode during recovery in one of the MH positive cases.
对在全身麻醉下从一个已知恶性高热（MH）家族的10名成员身上手术切除的离体肌肉条进行体外药理学测试，从而识别出3名MH阳性个体。MH易感性的诊断基于对低浓度咖啡因的敏感性增加以及MH易感肌肉中存在氟烷诱导的挛缩。15毫克/升的丹曲林钠完全预防了一名MH阳性病例的两条肌肉条中氟烷诱导的挛缩。文中描述了已知MH患者的成功麻醉管理，以及一名MH阳性病例在恢复过程中高热发作的成功处理。
