Tsunoda Y, Sakahira K, Nakano S, Matsumoto I, Yoshida T, Nagayama K, Ikezono E
Bull Tokyo Med Dent Univ. 1980 Jun;27(2):89-94.
The effects of acupuncture analgesia were studied using the change in halothane MAC in volunteers. Halothane MAC under electrical acupuncture stimulation was reduced to 86.2+/-11.1% from the control value. After naloxone administration the level of the MAC was raised to the control level and the increment was 19.1+/-14.8%. Naloxone itself did not change the halothane MAC in the same subjects. These results suggest that the changes in halothane MAC under acupuncture stimulation are caused by the release of an endogenous analgesic substance in the brain.
利用氟烷最低肺泡有效浓度（MAC）在志愿者身上的变化来研究针刺镇痛的效果。电针刺激下氟烷MAC从对照值降至86.2±11.1%。给予纳洛酮后，MAC水平升至对照水平，增幅为19.1±14.8%。纳洛酮本身在相同受试者中未改变氟烷MAC。这些结果表明，针刺刺激下氟烷MAC的变化是由脑内内源性镇痛物质的释放所引起的。
